84-1106-94　Telomeric Repeat Binding Factor 2 (Telomeric Repeat-binding Factor 2, TRF2, TERF2, Telomeric DNA Binding Protein, Telomeric Repeat Binding Protein 2, TTAGGG Repeat Binding Factor 2, TRBF2) 100ul　T2400-02D

特徴

• TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length.
• TRF2, like TRF1, contains a Myb-related DNA binding motif.
• It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes.
• TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini.
• The use of mutant forms of TRF2 has implied a role for TRF2 in the prevention of senescence in primary human cells.
• Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.
• TRF2 is overexpressed in a number of human tumors and overexpression of TRF2 may be oncogenic.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Positive Control: HeLa nuclear extract and HeLa whole cell lysate.
• Cellular Localization: Nuclear
• Storage and Stability:May be stored at 4°C for short-term only.
• For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C.
• Aliquots are stable for at least 3 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.