HIV-1, the viral cause of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle.
Activation of HIV-1 gene expression, by the transactivator Tat, is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site.
TARDBP is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription.
Recently it has been shown that TDP-43 accumulates abnormally in post-mortem brain tissue from individuals diagnosed with both ALS (Amyotrophic Lateral Sclerosis) and FTD (Frontal Temporal Dementia).
This observation provides a long sought connection between two disease that often over-lap clinically.
Applications:Suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence/Immunocytochemistry.
Optimal dilutions to be determined by the researcher.
Positive Control:Hela Whole Cell Extract
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris-glycine, 150mM sodium chloride, 0.05% sodium azide.
Specificity：Recognizes human TAR DNA Binding Protein 43 at ~45kD. Species Crossreactivity: primate, mouse, chicken, Xenopus, zebrafish.
Isotype：IgG
Calc Applications Abbrev：IC IF IHC WB
Calc Crossreactivity：Ch Hu Mk Mo Xe
Immunogen：Synthetic peptide mapping to a fragment of residues within amino acids350-414 of the C-terminal region of human TAR DNA Binding Protein 43. UniProt Accession: Q13148. Cellular Localization: Nuclear.
