84-1106-69　CD279 (CT) (Programmed cell death-1, PD-1) 100ug　P3120-62D

特徴

• CD279 is a single-pass type 1 membrane protein belonging to the CD28 family, and functions mainly as a negative regulator of T-cell activation.
• CD279 has two specific ligands; CD274 (PD-L1) and CD273 (PD-L2), and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance.
• CD279 is inducibly expressed by T-cells, B-cells, NK-T-cells and monocytes upon activation.
• Loss of CD279 function has been associated with a number of autoimmune diseases, including rheumatoid arthritis, type I diabetes and ankylosing spondylitis.
• Recent studies suggest that CD279 could be targeted therapeutically in the treatment of HIV infection to reduce T-cell exhaustion.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.5-1ug/ml.
• Detects a band at ~45kD in THP-1 cell lysates
• Immunohistochemistry (Paraffin): 2.5ug/mlOptimal dilutions to be determined by the researcher.
• Recommended Secondary Antibodies:I1903-30U: IgG, H&L, X-adsorbed (HRP) ShxRb
• Recommended Positive Control Tissue:Human brain
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.