84-1106-49　Synuclein, beta (SNCB, beta Synuclein, Phosphoneuroprotein 14, PNP14) 100ul　S9501-02F

特徴

• Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system.
• Alpha synuclein has been associated with several neurodegenerative diseases.
• A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD).
• Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD.
• The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein.
• Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies.
• Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively.
• The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations.
• Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function (1).
• Applications:Suitable for use in Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C.
• Aliquots are stable for at least 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.