84-1106-46　Synuclein, alpha (SNCA, Alpha Synuclein, MGC110988, Non-A beta Component of AD Amyloid, Non-A4 Component of Amyloid Precursor, NACP, PARK1, PARK4, Parkinson Disease Familial 1, PD1) 100ul　S9500-03H

特徴

• Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system.
• Alpha synuclein has been associated with several neurodegenerative diseases.
• A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD).
• Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD.
• The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein.
• Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies.
• Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively.
• The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations.
• Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function.
• Applications:Suitable for use in Immunohistochemistry.
• Other applications have not been tested.
• Recommended Dilution: Immunohistochemistry: 1:1000-1:2000Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.