p53DINP1 (p53-dependent damage-inducible nuclear protein 1).
The protein promotes p53 phosphorylation on Ser46 in response to DNA double strand breaks, thereby inducing apoptosis.
p53DINP1 is found in the nucleus and is ubiquitously expressed.
Expression is dramatically reduced in pancreatic ductal adenocarcinomas early in the development of pancreatic cancer.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1.0-2.0ug/ml, a lower band at 18kD was detected in human spleen, and mouse liver and kidney tissue lysates, which may represent the p53DINP1-b formImmunohistochemistry (Paraffin): 2ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography from serum.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human p53DINP1. Species Crossreactivity: Mouse and rat.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to 14 amino acids, MFQRLNKMFVGEVS, near the N-terminus of human p53DINP1.
