84-1105-34　［取扱停止］Serum Amyloid A1 (SAA1, Amyloid Fibril Protein AA, Amyloid Protein A, MGC111216, PIG4, SAA2, Serum Amyloid A Protein Precursor, SAA, Tumor Protein p53 Inducible Protein 4, TP53I4) 40ug　S1002-50B

特徴

• The serum amyloid A (SAA) family comprises a number of differentially expressed lipoproteins, acute phase SAA1 and SAA2, the former being a major component in plasma, and constitutive SAA's (C-SAAs).
• Although the liver is the primary site of synthesis of both SAA types, extrahepatic production has been reported.
• The in vivo concentrations of SAA increase by as much as 1000 fold during inflammation.
• Several studies have expressed SAA's importance in the diagnosis and monitoring of various diseases.
• Pathological SAA values are often detected in association with normal CRP concentrations.
• SAA rises earlier and more sharply than CRP
• SAA enhances the binding of HDL's to macrophages and thus helps the delivery of lipid to sites of injury for use in tissue repair.
• It is thus thought to be an integral part of the disease process.
• In addition, recent experiments suggest that SAA may play a 'housekeeping' role in normal human tissues.
• Elevated level of SAA over time predisposes secondary amyloidosis and extracellular accumulation of amyloid fibrils which are derived from a circulating precursor in various tissues and organs.
• The most common form of amyloidosis occurs secondary to chronic inflammatory disease, particularly rheumatoid arthritis.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilutions:ELISA: 0.05-0.2ug/mlWestern Blot: 0.5-2ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.