PIN1 is an essential peptidyl-prolyl isomerase that regulates mitosis, presumably by interacting with NIMA and attenuating its mitosis-promoting activity.
It displays a preference for an acidic residue N-terminal to the isomerized proline bond.
It catalyzes pSer/Thr-Pro cis/trans isomerizations.
PIN1 has been implicated in tau pathologies that underlie Alzheimer's disease.
PIN1 binds to tau-phosphorylated sites, specifically on the Thr231-Pro site, where it induces conformational changes.
PIN1 may be pivotal in maintaining normal neuronal function and preventing age-dependent neurodegeneration.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 0.05-0.2ug/mlWestern Blot: 0.5-1ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Reconstitute with sterile 40-50% glycerol, aliquot and store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：40ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder in PBS, pH 7.4, 0.02% sodium azide.
Specificity：Recognizes human PIN1 protein.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide within residues 50-100 of human PIN1 protein (Swiss Prot: Q13526).
