84-1102-72　p53 Binding Protein 1 (53BP1, 53-BP1, FLJ41424, MGC138366, p202, p53BP1, Tumor Protein 53 Binding Protein 1, Tumor Protein p53 Binding Protein 1, TP53BP1, Tumor Suppressor p53 Binding Protein 1) 100ug　P1001-25P

特徴

• P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase.
• Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double-strand breaks.
• This also suggests a role in DNA repair, maintaining genomic stability.
• Applications:Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilutions:Immunofluorescence (IC): 1:50-1:1000Western Blot: 1:2000-1:10,000
• Immunohistochemistry: Paraffin sectionsOptimal dilutions to be determined by the researcher.
• Positive Control:U205, 293T, and MO59K cell lysates (human) and MEF lysates (mouse)
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.