The Nurr1 gene encodes a member of the steroid-thyroid hormone- retinoid receptor superfamily.
The encoded protein may act as a transcription factor.
Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson's.
Nurr1 is a stem cell marker and cooperates with PITX3 to promote terminal maturation of murine and human embryonic stem cell cultures to a midbrain dopamine neuron phenotype.
In addition, Nurr1 is involved in the regulation of corticotropin-releasing hormone (CRH), which may be linked to and associated with rheumatoid arthritis.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C.
Aliquots are stable for at least 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.02% Sodium Azide
Specificity：This antibody is specific to the Nurr1 protein. Reacts with rat and mouse Nurr1. Species Crossreactivity: Human, mouse and Rat.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide comprising residues 513-526 [TERHGLKEPKRVEE] of the human Nurr1 protein. Reacts with rat and mouse Nurr1.
Shelf Life：1year
EU Commodity Code：30021010
商品名：Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2, HZF-3, Immediate-early Response Protein NOT, Intermediate Early Receptor Protein, NGFI-B/nur77 beta Type Transcription Factor Homolog, NOT, Nur Related Protein 1 Homolog, Nurr1, Orphan Nuclear Receptor NR4A2, Orphan Nuclear Receptor NURR1, RNR1, T cell Nuclear Receptor NOT, Transcriptionally Inducible Nuclear Receptor, TINUR, Transcriptionally Inducible Nuclear Receptor Related) 100ug
