The tachykinins belong to an evolutionary conserved family of peptide neurotransmitters that share the C-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an established role in neurotransmission.
The mammalian tachykinins include substance P, neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors.
Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine headache and allergy induced asthma.
Applications:Suitable for use in Immunohistochemistry and Western Blot.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (Paraformaldehyde-fixed cryostat or Vibratome sections): 1:100-1:1000 Western Blot: 1:500.
Detects truncated form of Substance P Receptor on 10ug of mouse brain lysates
Optimal dilutions to be determined by the researcher.
Positive Control:Spinal Cord
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：rat
Grade：Serum
Purity：Serum
Form：Supplied as a liquid. No preservative added.
Specificity：Recognizes rat Substance P Receptor expressing neurons in the central nervous system at 35kD. Species Crossreactivity: mouse and guinea pig.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Gp Mo Rt
Immunogen：Synthetic peptide corresponding to aa385-407 of rat Substance P Receptor (NM_003173).
