Communication between cells is often mediated by receptors on the surface of the target cell that are triggered by specific ligands released by other cells.
Receptor tyrosine kinase activity is strictly regulated by the binding of the appropriate ligand to the extracellular active site of the receptor.
These types of receptors play a role critical in the growth and differentiation of different cell types.
A muscle specific kinase recently identified, termed MUSK for muscle-specific kinase, and has been shown to be specifically expressed in the muscle cells within the neuromuscular junction.
MUSK has been shown to be part of the agrin signaling complex and plays an important role in the development and architectural maintenance of the neuromuscular junction.
Applications:Suitable for use in Immunohistochemistry, Immunofluorescence/Immunocytochemistry, Western Blot and Immunoprecipitation.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Positive Control:Mouse C2C12 cell lysate.
MUSK transfected COS7 cell lysate.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：200ug
Host：rabbit
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, 1mg/ml BSA, 0.05% sodium azide, 30% glycerol.
Specificity：Recognizes MUSK from mouse and rat tissue samples as well as COS7 cells transfected with rat MUSK.
Isotype：IgG
Calc Applications Abbrev：IC IF IHC IP WB
Calc Crossreactivity：Mo Rt
Immunogen：Fusion protein corresponding to aa210-304 from the extracellular domain of rat MUSK.
