Musashi1, a neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells.
Musashi-1 (Msi-1) has been shown to increase the accumulation of tau isoforms in intracellular inclusions in dementia.
It may play a role in the pathogenesis of various neurodegenerative disorders.
Musashi1 has also been detected in human tumor tissues such as gliomas and melanomas, suggesting its involvement in cancer development.
Msi-1 also appears to play be an vital role in the development of several types of carcinoma such as human hepatoma, and may be a useful molecular marker for tumor detection.
Applications:Suitable for use in Western Blot, Immunofluorescence/Immunocytochemistry and Immunohistochemistry.
Other applications not tested.
Recommended Dilutions:Immunohistochemistry (Frozen/Paraffin): 1:10-1:2000Western Blot: 1:500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human Musashi-1 RNA binding protein. Species Crossreactivity: rat and mouse.
Isotype：IgG
Calc Applications Abbrev：IC IF IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa5-21, APQPGLASPDSPHDPCK of human Musashi-1 binding protein.
