Principal Names: Metastasis associated 1 family, member 2 (MTA2); MTA1-L1 protein; p53 target protein in deacetylase complex; PID; Official Gene Symbol: MTA2 Gen Bank Accession Number: NP_004730 Gene ID: 9219 (Human) Gene Map Locus: 11q12-q13.1 (human) MTA2, a homologue of human MTA1 and MTA3, is a member of highly conserved MTA gene family.
It is a component of NuRD, an ATP-dependent nucleosome remodeling and histone deacetylase complex.
MTA2 is a nuclear protein that interacts with HDAC1 and HDAC2 and has a functional role in chromatin remodeling and deacetylase activity.
MTA2 specifically interacts with p53 and represses p53-dependent transcriptional activation, thereby regulating p53-mediated cell growth arrest and apoptosis.
It also inhibits the transcriptional activity of Estrogen receptor-alpha.
Northern Blot analysis detected a ubiquitous expression of MTA2.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C.
Aliquots are stable for at least 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by peptide immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
Specificity：Recognizes human MTA2. Species Crossreactivity: Chimpanzee, Rhesus Monkey
