The insulin signaling pathway plays a pivotal role in lifespan regulation and stress resistance in many diverse organisms.
Components of the JNK (c-Jun N-terminal kinase) signaling pathway have been shown to interact with the insulin signaling pathway.
The JNK family is a subgroup of the mitogen-activated protein kinase superfamily and is part of a signal transduction cascade that is activated by cytokines and by exposure to environmental stresses.
Thus, JNK1 plays a role in regulating both life span and stress resistance.
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilutions:Western Blot: 1:2000.
A band was identified at ~53kD for JNK1 alpha and ~42kD for JNK1 beta
Immunohistochemistry: Paraffin sectionsOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size:100ul
Host:rabbit
Source Antibody:nematode
Grade:Serum
Purity:Serum
Form:Supplied as a liquid, 0.05% sodium azide.
Specificity:Recognizes C. elegans JNK1. Does not crossreact with mammal JNK1.
Isotype:IgG
Calc Applications Abbrev:E IHC WB
Calc Crossreactivity:Ce
Immunogen:Recombinant corresponding to aa228-451 from the C-terminus of C. elegans JNK1 alpha protein. Cellular Localization: Neuronal