84-1101-15　Hox 11 (Homeobox Protein 11, Tcl-3) 100ug　H7022-35

特徴

• HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region.
• It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus.
• HOX11 is required for maintenance of the developing spleen and cell survival.
• The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus.
• It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator.
• The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t(10:14)(q24;qll) translocation.
• The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes.
• HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C.
• Aliquots are stable for at least 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.