84-1100-46　FXR (Farnesoid X-activated Receptor, Bile Acid Receptor, BAR, HRR-1, Nuclear Receptor Subfamily 1 Group H Member 4, NR1H4, Retinoid X Receptor-interacting Protein 14, RXR-interacting Protein 14, RIP14) 100ul　F9300-02

特徴

• The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and bind DNA as either homo- or heterodimers.
• The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, as well as several novel receptors including LXR (also referred to as RLD-1) and FXR.
• FXR and LXR fall into a category of proteins termed "orphan receptors" because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand.
• FXR has been shown to bind a class of lipid molecules called farnesoids.
• LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements.
• Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C.
• Aliquots are stable for at least 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.