84-1100-16　Dynamin-1-like Protein (DNM1L, Dynamin Related Protein 1, DRP1, EC 3.6.5.5, Dynamin-like Protein, Dnm1p/Vps1p-like Protein, DVLP) 100ul　D9901-30B

特徴

• A human dynamin-related protein, DRP1, contributes to mitochondrial division in mammalian cells.
• It plays this important role in mitochondrial fission at steady state and during apoptosis.
• DRP1 is required for proper cellular distribution of mitochondria, and in mutant neurons, mitochondria are largely absent from synapses, thus providing a genetic tool to assess the role of mitochondria at synapses.
• Cellular Localization: Cytoplasm; cytosol.
• Intracytoplasmic membrane; peripheral mambrane protein.
• Mainly cytosolic.
• Also membrane-associated.
• Localizes to mitochondia at spots of division events.
• Associated with peroxisomal membranes, it is recruited in part by PEX11B.
• May also be associtaed with endoplasmic reticulum tubules and cytoplasmic vesicles and gound to be perinuclear.
• Applications:Suitable for use in Western Blot and Immunohistochemistry (paraffin).
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.