84-1100-12　DISC1 (Disrupted in Schizophrenia 1, RP4-730B13.1, KIAA0457, SCZD9) 100ul　D8066-83A

特徴

• The 'Disrupted In Schizophrenia' gene locus DISC is associated with patients afflicted with schizophrenia as a result of chromosomal translocations.
• DISC-1 encodes a large protein predicted to contain a globular N-terminal domain and a helical C-terminal domain, both of which have the potential to form interactions with other proteins.
• DISC-1 interacts with proteins involved in the centrosome and cytoskeletal system, including MIPT3, MAP1A and NUDEL; proteins which localize receptors to membranes, including alpha-actinin 2 and beta 4-spectrin; and proteins which transduce signals from membrane receptors, including ATF-4 and ATF-5.
• Therefore, DISC-1 is thought to be involved in intracellular transport, neurite architecture and/or neuronal migration, all of which are thought to be pathogenic in the schizophrenic brain.
• Cellular Localization: DISC-1 localizes to the nucleus, whereas mutant DISC-1 localization occurs mainly in the cytoplasm.
• It colocalizes with the following organelle structure antibodies: PD1, calnexin, GIANTIN, 58K, Rab4, LAMP-1, RAP1, KDEL, and catalase.
• Positive Control: Human brain sections (neurons and glia)
• Applications:Suitable for use in Immunohistochemistry (Fr) (paraffin-embedded sections).
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C.
• Aliquots are stable for at least 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.