Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to hosphorylcholine.
Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
COFACTOR: Binds 2 calcium ions per subunit.
Subunit: Homopentamer.
Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
Cellular Localization:Secreted protein.
Alternative Products:2 named isoforms produced by alternative splicing.
Tissue Specificity:Found in plasma.
The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli.
It is induced by IL-1 and IL-6.
This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium.
Belongs to the pentaxin family.
Contains 1 pentaxin domain.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C.
Aliquots are stable for at least 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ul
Host：goat
Source Antibody：human
Grade：Serum
Purity：Serum
Form：Supplied as a lyophilized powder. Reconstitute in 100ul of sterile water. Centrifuge to remove any insoluble material.
Specificity：Specific for C-reactive protein by WB. Species Crossreactivity: Human
