84-1099-57　Capsaicin Receptor 100ug　C1078-06

特徴

• Vanilloid Receptor 1 (VR1), also known as capsaicin receptor, responds to both capsaicin, the pungent ingredient in hot peppers, and thermal stimuli within the noxious temperature range.
• This receptor is structurally related to the TRP family of ion channels and is predicted to contain 6 trans-membrane domains, a P-loop membrane domain and 3 ankyrin repeat domains.
• VR1 is highly permeable to divalent cations, including calcium and magnesium, as well as the monovalent cations sodium and potassium.
• Expression of VR1 appears to be limited to neurons within the sensory ganglia.
• Applications:Suitable for use in Immunofluorescence and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilutions:Immunohistochemistry (Frozen): 1ug/ml.
• Staining of VR1 in human glabrous skin results in the staining of epidermal and dermal cells, as well as free nerve fibers and Merkel cells
• Immunofluorescence: 1ug/ml.
• Staining of VR1 in human prostatic urethra results in fibrous staining within epithelial cells
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.