84-1099-38　［取扱停止］Brain Derived Neurotrophic Factor (BDNF) 100ul　B2700-02H

特徴

• BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development.
• The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia.
• BDNF may contribute to some pathologies such as depression, epilepsy, Alzheimer's and Parkinson's disease.
• BDNF promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.
• It is a ,ajor regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.
• The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1:500-1:2000.
• Detects a ~35kD band of proBDNF in rat brain extract
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.