BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development.
The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer?s, and Parkinson?s disease.
; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.
Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.
The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
SUBUNIT: Monomers and homodimers.
Binds to NTRK2/TRKB.
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C.
Aliquots are stable at -20°C for 12 months upon receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：500ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a lyophilized powder. Reconstitute with 500ul sterile dH2O. Centrifuge to remove any insoluble material.
Specificity：Recognizes human BSNF. Species Crossreactivity: mouse, rat. ≤0.1% cross reactivity with mouse NGF, recombinant human NT3 and NT4/5 has been recorded by dot blot analysis.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to aa129-138, HSDPARRGEL of huaman BDNF protein conjugated to KLH. Cellular Localization:Secreted protein. POst translation modification: Converted into mature BDNF by plasmin (PLG). Belongs to the NGF-beta family.
