84-1099-20　Amyloid beta A4 Precursor Protein-Binding, Family B, Member 1 (APBB1, Fe65, MGC:9072, RIR, Adaptor Protein FE65a2, Stat-like Protein) 100ul　A2275-61P2

特徴

• FE65 is a signaling adaptor of APP protein.
• The FE65/APP complex was shown to translocate into the cell nucleus and regulate gene expression.
• Genetic studies in mice validated FE65-APP interaction and molecular studies provided evidence on the role of the complex in abnormal signaling detected in brains of Alzheimer Disease patients.
• Applications:Suitable for use in Western Blot and Immunoprecipitation.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1:1000, a band is seen at ~100kD versus the predicted molecular weight of 77kD, which corresponds to earlier findings in literatureImmunoprecipitation: 2-10ugOptimal dilutions to be determined by the researcher.
• Positive Control:IMR32 neuronal cell lysate, HEK 293 cell lysate, or brain lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.