Signal Transducer and Activator of Transcription 2 (STAT2) is a 98kD member of the STAT family of cytoplasmic transcription factors.
STAT members generally mediate cytokine, growth factor and hormone receptor signal transduction.
STAT2 is associated with type I (a− and b--) interferon signaling.
All STATs contain an N-terminal oligomerization domain, a DNA-binding domain, and an SH2-association region.
STAT2 is phosphorylated at Y689 by receptor-associated Janus kinases (JAKs) leading to STAT2 dimerization and subsequent translocation to the nucleus to activate gene transcription.
Applications:Suitable for use in Flow Cytometry.
Other applications not tested.
Recommended Dilutions:Flow Cytometry: Use 10ul to label 1x10e6 cells using Daudi human Burkitt's lymphoma cell lineOptimal dilutions to be determined by the researcher.
Excitation:488nm
Emission:515-545nm
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Protect from light.
仕様
Size：100Tests
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.09% sodium. Labeled with Carboxyfluorescein.
Specificity：Recognizes human STAT 2 phosphoryated at Tyr689.
Isotype：IgG
Calc Applications Abbrev：FC
Calc Crossreactivity：Hu
Immunogen：Phosphopeptide containing Y689 site of human STAT2
