84-1097-94　NALP2 (NACHT-, LRR- and PYD-Containing Protein 2, PYRIN-containing APAF1-like Protein 2, Nucleotide-Binding Site Protein 1) 100ug　N0018-63D

特徴

• NALP2 (NAcht Leucine-rich repeat Protein 2, also known as PAN1) is a cytosolic, 121kD member of the NLRP family of proteins.
• It is expressed in macrophages and exhibits divergent effects on inflammation.
• Via NFkappaB, it suppresses TNF-alpha production in response to LPS; via procaspase-1, it promotes proIL-1Beta cleavage and release.
• Human NALP2 is 1062 amino acids (aa) in length.
• It contains an N-terminal Pyrin domain (aa 9-90), followed by a Nacht region and nine LRRs (aa 467-1033).
• Four alternate isoforms exist.
• Three show deletions of aa’s 109-132, 133-154 and 847-1062, respectively; a fourth shows a 38 aa substitution for aa’s 1-903.
• No close rodent counterparts have been reported.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1.0ug/ml
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Reconstitute to nominal volume by adding sterile 40-50% glycerol, aliquot and store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.