Interleukin 15 receptor alpha (IL-15 Ra) is a high affinity receptor that specifically binds IL-15 with high affinity and associates as a heterotrimer with the IL-2 receptors beta and gamma subunits to initiate signal transduction.
IL-15 Ra is expressed on a wide variety of T cells and B cells as well as non-lymphoid cells.
Signaling of IL-15 can occur in one of three ways; through the heterotrimeric complex of IL-15 Ra, IL-2 Rb and IL-2 Ryc, through the heterodimeric complex of IL-2 receptors beta and gamma common, or through a novel 60-65kD IL-15 RX subunit found on mast cells.
The binding of IL-15 to IL-15 Ra has been reported to antagonize the TNF-a-mediated apoptosis in fibroblasts by competing with TNFRI for TRAF2 binding.
IL-15 has a key role in promoting survival, proliferation and activation of natural killer (NK) and CD8+ T cells.
Applications:Suitable for use in Flow Cytometry.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Carboxyfluorescein conjugates are sensitive to light.
Note: Applications are based on unconjugated antibody.
仕様
Size：50ug
Host：goat
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS. Labeled with Carboxyfluorescein.
Specificity：Recognizes mouse IL-15R alpha.
Isotype：IgG
Calc Applications Abbrev：FC
Calc Crossreactivity：Mo
Immunogen：Recombinant corresponding to mouse IL-15Ra extracellular domain expressed in NS0 cells.
