84-1094-67　Adrenergic Receptor, Alpha 2c 50ul　A0906-80B

特徴

• Alpha 2A, 2B, and 2C adrenergic receptors are seven transmembrane receptors that couple to inhibitory G-proteins.
• Alpha 2C has a wide distribution pattern in the CNS.
• On neurons Alpha 2 adrenergic receptors are located on both pre- and postsynaptic domains where they mediate an inhibitory role in the central and peripheral nervous system.
• Alpha 2C has a wide distribution pattern in the CNS.
• At the spinal cord level the vast majority of alpha 2C is not of primary afferent origin; however, a small fraction of neurons in DRG do express mRNA for alpha 2C and harbor the protein.
• Colocalization has been observed between alpha 2C and enkephalin in the spinal cord dorsal horn, suggesting that alpha 2C may be expressed by a subset of spinal interneurons.
• The distribution pattern of alpha 2C suggests functions at several levels in the brain.
• Antibody showed positive staining in rat spinal cord dorsal horn, ventral horn motor neurons and retina.
• When examined in other brain regions known to express α2A staining was not observed.
• Applications:Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1:1000Immunohistochemistry (paraffin): 1:200-1:500Immunocytochemistry: 1:200-1:500Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.