84-1094-33　ANKTM1 (TRPA1, Transient Receptor Potential Cation Channel, subfamily A, Member 1, Ankyrin-like with transmembrane domains protein 1, Transformation-sensitive protein p120, Transient receptor potential cation channel subfamily A member 1) 100ul　A2295-16A

特徴

• Transient receptor potential ion channels (TRPCs) are a superfamily of six transmembrane segment-spanning, gated cation channels.
• TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction.
• It is a transformation-associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons.
• Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage.
• It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation.
• Applications:Suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence/Immunocytochemistry.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 2ug/ml.
• Detects a band at ~110kD
• Immunofluorescence (IC): 1:200Immunohistochemistry (Paraffin): 1:100-1:250Immunohistochemistry: 0.5-1ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.