84-1093-07　Jun B (JunB, Jun B proto-oncogene, Transcription factor jun-B) 100ug　J7998-10D

特徴

• The JunB transcription factor, also known as JunB proto-oncogene, JunB oncogene, transcription factor JunB, and transforming protein JunB, is a basic region leucine zipper DNA-binding protein, and a member of the Jun family of proteins, which also includes c-Jun and JunD.1 Jun proteins can homodimerize or heterodimerize with other Jun family members, or heterodimerize with Fos family members (cFos, FosB, Fra-1, and Fra-2) to form the activator protein 1 (AP-1) transcription factor.2-7 The various dimers differ in their ability to transactivate AP-1-dependent genes.
• Jun B8,9 and JunD1,10 are almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge.
• JunB and C-Jun antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin.11 Cyclin A is a direct transcriptional target of JunB driving cell proliferation.12 JunB is an important regulator of erythroid differentiation13, and is also important for the development of Th2 effector cells, normal Th2 cytokine expression pattern, and a complete Th2-dependent immune response in mice.14 JunB expression levels are increased in human colorectal adenocarcinoma specimens as compared to normal mucosa.15
• Applications:Suitable for use in ELISA and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunohistochemistry: 1:50-1:100Optimal dilutions to be determined by the researcher.
• Storage and Stability:For long-term storage, aliquot and store at -20°C.
• Aliquots are stable for at least 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.