Serum Amyloid P component (SAP) is a non-fibrillar plasma glycoprotein that belongs to the pentraxin family.
It is universally found in amyloid deposits (such as senile plaque and neurofibrially tangles in Alzheimers patients), and this is probably due to its specific calcium-dependent binding to motifs, which are present on all types of amyloid fibrils.
SAP is also found to prevent fibrillar breakdown by enzymes and it is believed that it helps maintains stability of the amyloid deposits.
It has been shown that SAP binds monocytes with high avidity, but does not bind to erythrocytes, NK cells, T-lymphocytes, or B-lymphocytes.
SAP production can be induced by exposure to IL-1, IL-6, and IFN-beta.
SAP levels in CSF can be useful for assessing cognitive impairment in AD patients.
Applications:Suitable for use in ELISA and Western Blot.
Other applications not tested.
Recommended Dilutions:ELISA: 0.05-0.2ug/ml Western Blot: 0.1-1.0ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：40ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.
Specificity：Recognizes human serum amyloid P component. Species Crossreactivity: mouse
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo
Immunogen：Synthetic peptide corresponding to residues near the N-terminus of human serum amyloid P-component conjugated to KLH.
