84-1091-92　Prostaglandin D2 Synthase (PTGDS) 100ul　P9053-24B

特徴

• The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2).
• PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system.
• PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation.
• PTGDS has also been implicated in the development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier.
• Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement (NREM) sleep.
• It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
• PTGDS is the most abundant protein in the cerebral spinal fluid and recent evidence suggests that PTGDS acts as a Beta-Amyloid chaperone and may have a role in the deposition of Ab plaques in Alzheimer’s disease.
• Applications:Suitable for use in Western Blot .
• Other applications have not been tested.
• Recommended Dilution:Western Blot: 2ug/ml Optimal dilutions to be determined by the researcher.
• Positive Controls:Human brain lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• For long-term storage, store at -20°C.
• Aliquots are stable for at least 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.