This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain.
The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane.
Mutations in this gene have been associated with Parkinson disease-8.
Applicatons:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Optimal dilution determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Reconstitute to nominal volume by adding sterile buffer.
Aliquot and store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ul
Host：sheep
Source Antibody：human
Grade：Serum
Purity：Serum
Form：Supplied as a lyophilized powder, No preservative added. Reconstitute with sterile 40-50% glycerol, dH2O.
Specificity：Recognizes human LRRK2.
Isotype：IgG
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu
Immunogen：A synthetic peptide (lkrkrkilssddslrss; aa 946-962) as part of human LRRK2 protein conjugated to the Blue Carrier Protein.
