This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a GTPase domain, a kinase domain, and a WD40 domain.
The protein is present largely in the cytoplasm, but also associates with lipid membranes.
Mutations in this gene have been genetically lined to late-onset, Lewy body Parkinson disease.
Applicatons:Suitable for use in ELISA, Immunohistochemistry (frozen sections) and Western blot.Other applications have not been tested
Positive Controls:Human lymphoblasts for IHC and human and mouse brain for Western blot
Storage and Stability:May be stored at 4°C for short-term only.
For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C.
Aliquots are stable for at least 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Tris-glycine, pH 7.2, 0.05% sodium azide.
Specificity：Recognizes human and mouse protein. Homology: 100% homology with human protein. 95% homology with mouse and rat proteins.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu Mo
Immunogen：A synthetic peptide made to a C-terminal region, within residues 2527-2577 of the human LRRK2 protein, conjugated to KLH. Cellular Localization: Cytoplasm. Membrane; Peripheral membrane protein.
