84-1091-45　Vaccinia Related Kinase 3 (VRK3) 100ul　V0499-16

特徴

• The vaccinia-related kinase (VRK) proteins are a new group of Ser/Thr kinases in the human kinome.
• This mammalian kinase family comprises three members, VRK1, VRK2, and VRK3 (1-3).
• The VRK1 has autophosphorylation activity and phosphorylates several transcription factors, including p53 (4), ATF2 (5), and c-Jun (6).
• VRK2 is associated with the endoplasmic reticulum (7).
• VRK3 suppresses ERK activity through direct interaction and activation of the MAP kinase phosphatase VHR (8).
• Further functional and structural analysis of VRK proteins will elucidate important new aspects of cell regulation.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:1000, incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight.
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.