This gene is highly similar to the v-src gene of Rous sarcoma virus.
This proto-oncogene may play a role in the regulation of embryonic development and cell growth.
The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase.
Mutations in this gene could be involved in the malignant progression of colon cancer.
Two transcript variants encoding the same protein have been found for this gene.
Applications:Suitable for use in Western Blot, Immunocytochemistry and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000.
Detects phospho-Src (Tyr418) in RIPA lysate of E16 rat heart.
Optimal dilution to be determined by researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.3, 1mg/ml BSA (IgG, protease-free), 0.05% sodium azide, 50% glycerol.
Specificity：Recognizes phosphorylated human Src (Tyr418). Species Crossreactivity: mouse and chicken.
Isotype：IgG
Calc Applications Abbrev：IC IHC WB
Calc Crossreactivity：Ch Hu Mo
Immunogen：Synthetic peptide corresponding to amino acid region encompassing the human, mouse, rat, chicken, and frog phospho-Src (Tyr418). Species Sequence Homology: rat and frog.
