Integrin beta1 is a transmembrane glycoprotein that forms noncovalent complexes with various alpha integrin subunits to form the functional receptors that bind to specific extracellular matrix proteins.
Integrin receptors are involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells.
Interactions between integrins and extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression.
Phosphorylation of threonines 788 and 789 on integrin beta1 receptor may play a key role in cell-cycle dependent regulation.
Applications:Suitable for use in Western Blot.
Other applications not tested
Recommended Dilutions:Western Blot: 1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in Dulbecco’s PBS (without Mg2+ or Ca2+), pH 7.3, 1mg/ml BSA, 0.05% sodium azide, 50% glycerol.
Specificity：Recognizes human integrin beta1 receptor at ~130kD
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Phosphorylated synthetic peptide corresponding to amino acid residues surrounding and including threonine 788/789 of the human beta1 integrin. The immunogen sequence is 100% identical in mouse, rat and chicken integrin beta1. Epitope: Phosphothreonine 788/789
