84-1090-17　TAB1 (TGF-beta-activated Kinase 1 and MAP3K7-binding Protein 1, TGF-beta-activated Kinase 1-binding Protein 1, TAK1-binding Protein 1, 3'-Tab1, Mitogen-activated Protein Kinase Kinase Kinase 7-interacting Protein 1, MAP3K7IP1) 100ug　T0291-86

特徴

• TAK1-binding protein 1 (TAB1), also known as MAP3K7IP1, is an activator of the MAP3K TAK1.
• The C-terminal 68 amino acids of TAB1 are sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF-β, suggesting that TAB1 may function as a signaling intermediate between TGF-β receptors and TAK1.
• TAB1 also promotes autophosphorylation and activation of the MAPK p38α.
• Applications:Western Blot: 1ug/mlImmunocytochemistry: This antibody will detect human TAB1 in cells.
• The working dilution is 5-15ug/ml.
• Optimal dilutions should be determined by the individual laboratory.
• Storage and Stability:Lyophilized powder may be stored at 4°C for short-term only.
• Reconstitute to nominal volume by adding sterile PBS with 40-50% glycerol and store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.