84-1089-73　Paraoxonase 3 (PON3, Lactonase 3) 100ug　P3107-80

特徴

• The paraoxonase (PON) gene family of antioxidant enzymes includes three known members located adjacent to each other on chromosome 7.
• Paraoxonase/lactonase 3 (PON3) is a 354 amino acid, 39.6kD protein that is secreted into the bloodstream and associates with high-density lipoprotein (HDL).
• PON3 has lactonase activity (EC 3.1.1) and rapidly hydrolyzes lactones.
• PON3 exhibits no paraoxonase and very limited arylesterase activities.
• PON3 is an important antioxidant and can inhibit the oxidation of low-density lipoprotein (LDL), a function that may slow the initiation and progression of atherosclerosis.
• PON3 is glycosylated at Asn-323.
• Alternatively spliced variants encoding different protein isoforms have been described; however, only one has been fully characterized.
• Human PON3 shares 81% amino acid identity with mouse and rat PON3.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 0.5ug/mlOptimal dilutions to be determined by the researcher.
• Recommended Secondary Antibodies:I1904-28C: IgG, H&L (HRP) Pab Dk x GtI1904-28G: IgG, H&L (HRP) (X-Adsorbed) Pab Dk x Gt
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile PBS, 0.02% sodium azide.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.