Janus Kinase 2 (Jak2) belongs to a family of protein tyrosine kinases that couple to cytokine receptors and are activated by ligand binding to these receptors.
Activation of Jak2 and other family members Jak1, Jak3, and Tyk2 occurs via phosphorylation at two adjacent tyrosine residues as well as potentially one or more serine residues.
Jaks activate members of the STAT family of transcription factors by phosphorylating critical tyrosine regulatory sites.
Jak2 plays an essential role in interferon gamma signaling.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilutions:Western Blot: 1ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months after receipt at -20°C.
Reconstitute with sterile PBS.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：goat
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 500ul sterile PBS.
Specificity：Recognizes mouse Jak2. Species Crossreactivity: rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Mo Rt
Immunogen：Recombinant protein corresponding to Gly2-Val63 from mouse JAK2, expressed in E. coli. UniProt Accession: Q62120
