84-1089-21　［取扱停止］Interleukin 17 Receptor D (IL-17RD) (PE) 100Tests　I8439-21E

特徴

• Interleukin 17 receptor D (IL-17 RD), also known as SEF (similar expression to FGFs), is a type I transmembrane protein that is found in both the cytoplasm and plasma membrane.
• The gene for this protein belongs to a synexpression group originally identified in zebrafish and SEF is expressed along with FGF-3, -8, sprouty-2 (SPRY2) and SPRY4.
• By alternate splicing, two transcript variants, potentially encoding three protein isoforms exist.
• One is a full-length long form, one a shortened form that uses an alternate start site, and one an alternate splice form that removes the classic signal sequence.
• These isoforms have different expression patterns, subcellular localization, and function.
• The membrane-bound long form of human IL-17 RD is synthesized as a 739aa precursor protein with a putative 27aa signal peptide, a 272aa extracellular domain, a 20aa transmembrane segment and a 420aa cytoplastic domain.
• The extracellular domain contains one Ig-like domain and a fibronectin type III motif.
• The cytoplasmic domain shares homology with the intracellular domains of IL-17 receptor family members and shows one TIR (Toll/IL-1 Receptor) domain and a putative TRAF6-binding motif.
• Applications:Suitable for use in Flow Cytometry.
• Other applications not tested.
• Recommended Dilutions:Flow Cytometry: 10ul to label 1x10e6 cellsOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C before opening.
• DO NOT FREEZE! StableStore product at 4°C in the dark.
• DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: PE conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap