Interferon Regulatory Factor 2 (IRF2) belong to the interferon regulatory transcription factor family.
IRF2 functions as a regulator of type I interferons influencing cellular proliferation and immune response through transcriptional regulation.
IRF2 competitively inhibits IRF1 gene activation, as well as, stimulating transcription on its own.
Over-expression of IRF2 in NIH3T3 cells leads to transformation, whereas, loss of IRF2 expression in knock out mice leads to a variety of abnormalities including loss of NK cells due to increased apoptosis.
Applications:Western Blot: An antibody concentration of 0.5ug/ml is recommended.
Optimal dilutions should be determined by the individual laboratory.
Storage and Stability:Lyophilized powder may be stored at 4°C for short-term only.
Reconstitute to nominal volume by adding sterile PBS with 40-50% glycerol and store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：goat
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder from a 0.2um filtered solution in PBS with 5% trehalose. Reconstitute with sterile PBS, 40-50% glycerol. If 0.1ml is used, the concentration will be 1mg/ml.
Specificity：Detects human IRF2.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：E. coli-derived recombinant human IRF2 (rhIRF2; aa151-349)
