84-1087-08　Integrin, beta5 100ul　I7661-43D

特徴

• Integrins are a/b heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival.
• The integrin family contains at least 18 a and 8 b subunits that form 24 known integrins having distinct tissue distribution and overlapping ligand specificities.
• Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with extracellular environment (inside-out signaling).
• The aVb5 integrin is expressed in various tissues and cell types, including endothelia, epithelia and fibroblasts.
• It plays a role in matrix adhesion to VN, FN, SPARC and bone sialoprotein and functions in the invasion of gliomas and metastatic carcinoma cells.
• aVb5 integrin plays a major role in growth-factor-induced tumor angiogenesis, where cooperative signaling by the aVb5 integrin and growth factors regulates endothelial cell proliferation and survival.
• Applications:Suitable for use in Western Blot, Immunoprecipitation, Immunofluorescence and Immunocytochemistry.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1:1000 Immunoprecipitation: 1:50 Immunofluorescence (IC): 1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.