84-1086-73　Telomerase (TP1, p80 Telomerase Homolog, Telomerase-Associated Protein 1, Telomerase Protein 1, Telomerase Protein Component 1) 100ug　T2399-97

特徴

• Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes.
• Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TP1).
• Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death.
• High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TP1 do not correlate with malignancy.
• At least two isoforms of TP1 are known to exist.
• Applications:Suitable for use in ELISA, Western Blot, Immunofluorescence and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunofluorescence: 20ug/mLWestern Blot: 1-2 ug/ml
• Immunohistochemistry (paraffin): 2.5ug/mLOptimal dilutions to be determined by the researcher.
• Positive Control:Human Kidney Tissue Lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C.
• Aliquots are stable for at least 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.
• Sold under license from Geron