84-1086-56　Neuritin 100ug　N2116-88

特徴

• As the nervous system of a complex organism develops, it establishes functional networks through the growth and retraction of synaptic connections from growing axons and dendrites.
• This synaptic remodeling involves neurotransmitter signaling, activation of neurotrophin receptors and alterations in gene expression (reviewed in 1).
• One such gene whose expression is increased by neural activity is neuritin, a GPI-anchored protein that is expressed in postmitotic differentiating neurons of the developing nervous system.
• Its expression is also induced by the neurotrophins BDNF and NT-3.
• Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic neuronal cultures, suggesting that neuritin may play a role as a downstream effector of activity-induced neurite outgrowth.
• More recent experiments have shown that neuritin is required for the androgen-induced axonal elongation in motor neurons and is upregulated following spinal cord injury, suggesting that neuritin may also play a role in survival and axonal regeneration.
• Applications:Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilutions:Immunofluorescence: 20ug/mlWestern Blot: 10ug/mlImmunohistochemistry: 5ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:Daudi cell lysate and mouse heart tissue lysate
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.