MCG10 is a member of the KH-domain RNA-binding protein family.
Proteins of this family also referred to as alpha-CPs, bind to RNA with specificity for C-rich pyrimidine regions.
Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions (1).
MCG10 is induced by p53 and DNA damage via two p53-responsive promoter elements.
Its overexpression in transfected cells results in the suppression of cell proliferation by inducing apoptosis and cell cycle arrest in G2-M (2).
Decreased expression of one isoform of MCG10 has been observed in many forms of lung cancer, leading to speculation that MCG10 can act as a tumor suppressor (3).
Multiple alternatively spliced isoforms of MCG10 have been identified.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 0.5-1 ug/ml
Optimal dilutions to be determined by the researcher.
Positive Control:HeLa cell lysate
Storage and Stability:May be stored at 4°C for short-term only.
For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C.
Aliquots are stable for at least 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human MCG10.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：17 amino acid peptide from near the carboxy terminus of humanMCG10 (GenBank accession no. EAW65166).
