The D2 dopamine receptor is one of five (D1 to D5) receptors for dopamine.
Its activity is mediated by G proteins which inhibit adenylyl cyclase.
It interacts with GPRASP1, neurabin-2, CLIC6, CADPS and CADPS2.
It is a transmembrane protein that belongs to the G-protein coupled receptor 1 family.
The unprocessed precursor has a length of 443 amino acids and an estimated molecular mass of 50.6kD.
Genetic variations in DRD2 may determine the genetic susceptibility to alcoholism.
A missense mutation in this gene causes myoclonus dystonia and several other defects in this gene are thought to be involved in psychiatric disorders, especially in schizophrenia.
Applications:Suitable for use in ELISA, Western Blot and Immunocytochemistry.
Other applications not tested.
Recommended Dilution:Dilute ≥1:8 in 1% normal goat serum, TBS/Tween-20 before use.
Optimal dilutions to be determined by the researcher.
Included Control Peptide:D9000-06L1: Dopamine Receptor D2 Control Peptide (DRD2)Reconstitute with 600ul of reconstituted antibody.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months at -20°C.
Reconstitute with sterile PBS, 10mg/ml BSA.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：5ml
Host：rabbit
Grade：Purified
Purity：Purified
Form：Supplied as a lyophilized powder. Reconstitute with 5ml PBS, 10mg/ml BSA.
Specificity：Recognizes the D2 Dopamine Receptor (DRD2). Reactivity with DRD2 (aa272-282) is 100% and 60% for full-length DRD2. Detects both the D2S and D2L Dopamine Receptors in Western Blot. Does not crossreact with the D1, D3, D4 or D5 Dopamine Receptors.
Isotype：IgG
Calc Applications Abbrev：E IC WB
Immunogen：Dopamine Receptor D2 (Cys271-272-282) covalently attached onto a carrier protein.
