84-1084-72　［取扱停止］SNAP 25 (SNAP25, synaptosomal-associated protein, 25kDa , HGNC:11132, FLJ23079, SNAP, SNAP-25, bA416N4.2, dJ1068F16.2 , synaptosomal-associated protein 25) 100ug　S1014-70G

特徴

• SNAP-25 is a presynaptic plasma membrane protein which is essential for Ca2+-regulated exocytosis of neurotransmitters.
• SNAP-25 has been shown to bind to and negatively modulate Ca2+ channels, increasing the speed of neurotransmitter release.
• SNAP-25 is expressed by neurons and neuroendocrine cells as two predominant isoforms; SNAP-25a and SNAP-25b.
• SNAP-25a is expressed early in development, whereas SNAP-25b expression is linked to synaptogenesis.
• AHP1123 is expected to recognize both isoforms.
• SNAP-25 may be a possible therapeutic treatment for sufferers of hyperactivity disorders, while SNAP-25 based peptides may be a possible treatment for involuntary muscle spasms.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:Peptide ELISA: antibody detection limit dilution 1:32,000.
• Western Blot: Approx 22kD band observed in Human Brain and Mouse Brain lysates (calculated MW of 23.3kD according to NP_003072.2 and NP_570824.1).
• Recommended concentration: 0.01-0.03ug/ml
• Optimal dilution determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.