84-1083-22　［取扱停止］Neuropeptide Y2 Receptor (NPY Y2R) 100ug　N2176-63N

特徴

• Neuropeptide Y (NPY), a neuropeptide colocalized and abundantly released with the neurotransmitter norepinephrine in nervous system, synthesized by postnatal olfactory epithelium of sustentacular cells.
• It promotes the proliferation of postnatal neuronal precursor cells and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system.
• NPY a 97aa peptide in mouse, human (chr 7p15.1) and 98aa in rat has a mol.
• wt of 11kD.
• NPY shows sequence homology to Peptide YY (PYY) and over 50% homology in amino acid and nucleotide sequence to Pancreatic Polypeptide (PNP or PPY), all of these homologous peptides has a 36aa mature peptide characterized by a hairpin loop.
• NPY2R, an integral membrane protein with 385aa in mouse, 417 in rat and 381aa in human (chr 4q31).
• This receptor mediates its action by association with G proteins that activate a phospatidylinositol-calcium second messenger system.
• Applications:Suitable for use in ELISA.
• Western Blot, though not tested, may potentially be used as an application.
• Other applications not tested.
• Recommended Dilution:ELISA: 0.5-1ug/ml; Control peptide ( N2176-63P ) can be used to coat ELISA plates at 1ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• For long-term storage, store at -20°C.
• Aliquots are stable for at least 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.