Neuropeptide Y (NPY), a neuropeptide colocalized and abundantly released with the neurotransmitter norepinephrine in nervous system, synthesized by postnatal olfactory epithelium of sustentacular cells.
It promotes the proliferation of postnatal neuronal precursor cells and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion and potent vasoactive effects on the cardiovascular system.
NPY precursor is a 97aa peptide in mouse, human (chr 7p15.1) and 98aa in rat has a MW of 11kD.
The precursor contains a 28aa signal peptide, 29-64 (active processed NPY peptide) followed by the C-flanking peptide of NPY.
NPY shows sequence homology to Peptide YY (PYY) and over 50% homology in aa and nucleotide sequence to Pancreatic Polypeptide (PNP or PPY), all of these homologous peptides has a 36aa mature peptide characterized by a hairpin loop.
Applications:Suitable for use in ELISA.
Other potential application, though not tested is Western Blot.
Other applications not tested.
Recommended Dilution:ELISA: 0.5-1ug/ml; Control peptide can be used to coat ELISA plates at 1ug/mlOptimal dilutions to be determined by the researcher.
Control Peptide:N2176-60L: Neuropeptide Y, Mouse, Control Peptide
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.1% BSA.
Specificity：Recognizes mouse Neuropeptide Y.
Isotype：IgG
Calc Applications Abbrev：E
Calc Crossreactivity：Mo
Immunogen：Synthetic peptide corresponding to 9aa near the N-terminus of mature mouse NPY, conjugated to KLH. Species Sequence Homology: rat, human and chicken (100%).
